Compared with persons who did not develop new CMBs at follow-up, those who developed incident CMBs were older; were more likely to be male, smoke, and have diabetes mellitus; and had a lower BMI, a higher level of diastolic blood pressure, and a larger volume of WMLs, subcortical infarcts, and prevalent CMBs at baseline (all p < 0.05), but the 2 groups did not differ significantly in educational attainments, systolic blood pressure, hypertension, use of antihypertensive drugs, total cholesterol, and APOE ε4 allele (table 1). This evidence concerns the gene APOE and diabetes mellitus.