APOE and hypertensive disorder: Compared with persons who did not develop new CMBs at follow-up, those who developed incident CMBs were older; were more likely to be male, smoke, and have diabetes mellitus; and had a lower BMI, a higher level of diastolic blood pressure, and a larger volume of WMLs, subcortical infarcts, and prevalent CMBs at baseline (all p < 0.05), but the 2 groups did not differ significantly in educational attainments, systolic blood pressure, hypertension, use of antihypertensive drugs, total cholesterol, and APOE ε4 allele (table 1).