Mendelian randomization has been used in clinical research to investigate potential etiologic mechanisms, such as the causal effects of low-density lipoprotein cholesterol (LDL-C),14 systolic blood pressure,15 and CRP (C-reactive protein)16 on coronary heart disease, validate and prioritize novel drug targets, such as IL-6 (interleukin-6) receptor,17 and increase understanding of current therapies, for example, statins.18 This evidence concerns the gene CRP and coronary artery disorder.