PTEN and gallbladder cancer: For example, PTENP1 shares conserved miRNA seed target sites with PTEN 3′-UTR for the miR-17, miR-21, miR-214, miR-19, and miR-26 families, thereby modulating the expression of tumor suppressor gene PTEN [48]; lncRNA H19 regulates FOXM1 expression by competitively binding endogenous miR-342-3p, thus promoting cell proliferation and invasion in gallbladder cancer [49].