EGFR and non-small cell lung carcinoma: In the LUX-Lung 7 trial, a phase 2B, open-label randomized controlled trial enrolling patients with NSCLC harboring susceptible EGFR mutations, the patients who received afatinib had a significantly longer PFS (median: 11.0 vs. 10.9 months, p = 0.017) and time-to-treatment failure (median: 13.7 vs. 11.5 months, p = 0.0073) than those who received gefitinib as the initial EGFR TKI [10].