CDH1 and cholangiocarcinoma: However, the present study is the first one to report that co-culture with adipocytes could induce the representative mesenchymal properties in CCA cells, which resulted in alterations in cell polarity, cell shape, loss of cell-to-cell adhesion regulated by E-cadherin, and expressions of mesenchymal biomarkers, indicating the acquired EMT induced by CCA associated adipocytes.