Further analysis showed that expression of p53R2 was significantly correlated with T stage (Table 2, P = 0.043) and there was no significant association between p53R2 expression and other clinicopathological features, such as patient sex, age, lymph node metastasis, clinical stage, therapeutic regimen, relapse (Table 2, P > 0.05). This evidence concerns the gene RRM2B and metastatic malignant neoplasm in the lymph nodes.