Despite the adjustments for hemoglobin and albumin levels (model 5: HR, 2.83; 95% CI, 1.70–4.70) and further adjustment for creatinine and LVEF levels (model 6: HR, 2.58; 95% CI, 1.54–4.32), RDW ≥ 14.5% was independently associated with a higher risk of major composite CV outcomes in patients with CKD. This evidence concerns the gene ALB and chronic kidney disease.