The two clusters were correlated with six molecular subtypes (Chi-square test, P < 0.001) and patients age (Chi-square test, P = 0.05), but not correlated with gender, tumor location, BRAF /KRAS / TP53 mutation status or adjuvant chemotherapy treatment (Chi-square test, P > 0.05) (Fig. 2c). This evidence concerns the gene KRAS and neoplasm.