ALB and blood coagulation disease: The following events occur in cases of liver failure: liver cell necrosis occurs; liver function is impaired; enzyme synthesis is reduced; disorders in detoxification, excretion and transport capacity occur; bilirubin, amino acids and other substances are released into the blood and accumulate; serum bilirubin and transaminase levels increase; and the synthesis of proteins and coagulation factors decreases, resulting in decreased Alb levels and the development of coagulation disorders.