Furthermore, it is interesting to note that upregulation of genes, such as ANKRD22, FRMD6, and KIR3DL2, and down-regulation of genes, such as TIMP3, SAP25, NAPSA, and TIMP are associated with a worse prognosis in cancer, are also associated with a worse prognosis in AdHF. The gene discussed is KIR3DL2; the disease is cancer.