CASC3 and acute lymphoblastic leukemia: Of note, Ph+ALL cell lines (median IC50: 11.4 nM; Mean ± SD: 11.4 ± 3.1 nM) were significantly more sensitive to BTZ than t(17;19)-ALL cell lines (20.8 nM; 25.2 ± 15.7 nM; p = 0.047 by Mann-Whitney test) and B-other ALL cell lines (13.9 nM; 13.4 ± 4.7 nM; p = 0.038), and tended to be more sensitive than MLL+ALL cell lines (14.6 nM; 16.7 ± 7.6 nM; p = 0.052) and t(12;21)-ALL cell lines (17.1 nM; 15.5 ± 3.5 nM; p = 0.059).