Among all the BCP-ALL cell lines (S2 Table and Fig 5A), the t(17;19)-ALL cell lines (median IC50: 26.5 nM; Mean ± SD: 33.9 ± 30.2 nM) were significantly more resistant to CFZ than the Ph+ALL (5.68 nM; 5.9 ± 4.0 nM; p < 0.01), MLL+ALL (5.36 nM; 5.2 ± 4.1 nM; p < 0.01), t(1;19)-ALL (4.66 nM; 5.1 ± 3.8 nM; p < 0.01), t(12;21)-ALL (5.81 nM; 5.6 ± 0.4 nM; p = 0.034), and B-other ALL cell lines (5.16 nM; 4.5 ± 2.2 nM; p < 0.01). The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.