Of note, even in Ph-negative BCP-ALL cell lines, IKZF1 deletion and biallelic loss of CDKN2A were independently associated with higher BTZ sensitivity, suggesting that frequent association of IKZF1 deletion and biallelic loss of CDKN2A may somehow contribute to the higher BTZ sensitivity of Ph+ALL cell lines. Here, CASC3 is linked to acute lymphoblastic leukemia.