The IC50 of 25 BCP-ALL cell lines carrying IKZF1 deletion (median IC50: 11.4 nM; Mean ± SD: 10.8 ± 4.0 nM) was significantly lower than that of 54 BCP-ALL cell lines not carrying the deletion (14.1 nM; 15.3 ± 7.0 nM; p = 0.0031 by Mann-Whitney test) (Fig 2B). The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.