AR and posterior cortical atrophy: Cells within the basal layer are characterized by the absence of AR protein expression and are thus androgen‐independent, yet responsive to androgens to induce differentiation.33 The PCa cell lines PC3 and Du‐145 are AR‐negative and may be considered as basal‐like models of PCa.34 Although these two cell lines have lost expression of several basal markers, such as p63,35 possibly through adaptation to long‐term ex vivo two‐dimensional culture, several characteristics are retained.