AHSG and urolithiasis: In consequence, if we can stop the release of the CCL-2, OPN, and ROS, inhibit the oxidative stress and inflammatory injury and apoptosis of renal tubular epithelial cells caused by crystal reaction, and learn more about the regulation mechanism of Fetuin-A, it will help us to understand more about the formation mechanism of Randall’s plaques, and may provide new ideas for further elaboration of the pathogenesis of urolithiasis.