Fukada et al. found that Zip13-KO mice show delayed growth and abnormalities in hard and connective tissue development [32], and a loss of function mutations were found in a novel variant of human Ehlers–Danlos syndrome (EDS): Spondylocheirodysplastic Ehlers–Danlos syndrome (SCD-EDS; OMIM 612350), demonstrating the importance of ZIP13 in the development and homeostasis of hard and connective tissues (Table 2) [32,83]. The gene discussed is SLC39A13; the disease is Ehlers-Danlos syndrome.