In 2015, Prajapati and collaborators [108] found that TNF-α was able to both trigger cell death in SH-SY5Y cells, as well as to sensitize SH-SY5Y to apoptosis in the presence of different PD stress conditions (i.e., MPTP, 6-OHDA, Rotenone). The gene discussed is TNF; the disease is Parkinson disease.