On the other hand, tumour infiltration by immunosuppressive cells, such as regulatory T-cells (Tregs) or immunosuppressive tumour-associated macrophages (M2 TAMs), secreting anti-inflammatory cytokines, such as TGFβ and IL-10 and pro-angiogenic factors, or expressing a PD-ligand, relates to unfavourable prognosis. The gene discussed is IL10; the disease is neoplasm.