After adjustment for age, sex, BMI, diabetes, hypertension, smoking, plasma lipids, blood immune cell counts, morning saliva cortisol, cortisol response to the stress test and medication in a multivariable linear regression analysis, evening saliva cortisol remained a potent determinant of stress-induced S100A8/A9 increase (Table 2). The gene discussed is S100A8; the disease is hypertensive disorder.