The variation in cortisol levels correlated negatively with the S100A8/A9 response at 24 h after stress in CAD patients (r = −0.486, p = 0.016) (Fig. 3a), but no such correlation was present in healthy controls (r = −0.154, p = 0.442) (Fig. 3b). The gene discussed is IGKV1D-22; the disease is coronary artery disorder.