Actually, we found that TET1 is highly expressed not only in MLL-rearranged AML as we reported previously19, but also in AML carrying t(8;21); moreover, depletion of Tet1 expression also significantly inhibited t(8;21) fusion gene-induced colony-forming/replating capacity of mouse bone marrow (BM) progenitor cells (Supplementary Fig. 3). The gene discussed is KMT2A; the disease is acute myeloid leukemia.