UC-514321 showed an enhanced effect in repressing the viability of TET1-high AML (including MONOMAC-6, THP-1, and KASUMI-1) cells, as compared with NSC-370284 and other JAK/STAT inhibitors, e.g. Pacritinib42, KW-244943, STAT3/5 inhibitor Stattic44, or STAT5 inhibitor sc-35597945 (Fig. 4b–d). This evidence concerns the gene TET1 and acute myeloid leukemia.