OTUD1 and glioblastoma: To determine the clinical relevance of the above findings in advanced human cancers, we first analyzed the TCGA database and found that the OTUD1 gene is lost or even deleted in many tumor types as revealed by GISTIC analysis35, the total percentage is more than 50% in glioblastoma, melanoma and lung cancer (Fig. 8a; Supplementary Table 2).