Tumor volume of HCCC-9810-B7-H4- and QBC939-control-derived xenografts was 256.84 ± 26.64 mm3 and 325.66 ± 63.27 mm3, which was significantly larger than that derived from HCCC9810-control and QBC939-B7-H4 shRNA groups, respectively (74.35 ± 8.68 mm3 and 92.26 ± 12.74 mm3, respectively, p < 0.001, Fig. 4c, d). This evidence concerns the gene VTCN1 and neoplasm.