VTCN1 and intrahepatic cholangiocarcinoma: Recently, several studies reported that B7-H4 had an oncogenic role in multiple tumor types and high level of B7-H4 could serve as a biomarker for predicting poor prognosis of cancer patients.12,15 In the present study, our results also showed that ICC patients with high expression of B7-H4 in tumor tissues had poor prognosis.