AFAP1 and open-angle glaucoma: The two lead SNPs for AFAP1 (rs4619890 and rs11732100) previously reported to be associated with POAG at genome-wide significance18, 20, were moderately correlated with our lead SNP rs28795989 in European-Ancestry populations (R2 = 0.25 and 0.51, respectively) (Supplementary Table 4).