This concern is mitigated by findings from our case–control analysis of glaucoma, which show that 15 of the novel loci associated with IOP are also associated with glaucoma at Bonferroni or nominal level of significance, including three loci (AFAP1, FOXC1, and PKHD1) previously found in association with glaucoma. The gene discussed is FOXC1; the disease is glaucoma.