CD8A and dengue disease: In particular, the aim is to define the epitope breadth/repertoire and the targets of CD4 and CD8 responses; to derive sets of HLA class I and class II predicted epitopes covering the entire ZIKV proteome; to define phenotypes and T-cell subsets associated with CD4 and CD8 specific T cells; to identify the major type-specific and crossreactive B-cell epitopes on ZIKV, and to assess the role of flavivirus antibodies in protective and pathogenic immunity (e.g. related to prior dengue infections, dengue, and yellow fever vaccines).