PHGDH and cancer: Based on metabolomic and protein expression data, proteins involved in the lactate production (LDH-A), serine and one carbon metabolism (phosphoglycerate dehydrogenase and serine hydroxymethyltransferase 2), glutaminolysis (glutaminase), and fatty acid biosynthesis (fatty acid synthase), have been proposed for cancer therapy [85] and may also represent attractive therapeutic targets in TC.