In glioblastoma, and other tumors, EZH2 is overexpressed and acts as an oncogene with multiple mode of actions including cell invasion utilizing largely tumor-specific mechanisms [121, 122], cell cycle progression, maintenance of cell stemness [123], and, last but not least, the development of drug resistance [123, 124] and inhibition of apoptosis [119]. The gene discussed is EZH2; the disease is glioblastoma.