The effects of rs5882 and rs708272 CETP gene polymorphisms on dietary fatty acids, alcohol consumption, and adherence to Med diet were evaluated in eight observational studies; of them three studies found significant interaction of CETP gene polymorphisms and alcohol consumption in relation to coronary heart disease (CHD) (Table 3) and three others found significant interaction of CETP gene polymorphisms and alcohol or dietary fat intake in relation to total cholesterol (TC) and HDL-C (Table 4). This evidence concerns the gene CETP and coronary artery disorder.