CETP and coronary artery disorder: In a meta-analysis, after adjustment of confounding factors, the Taq1B (rs708272) variant of CETP gene exhibited a significant association with HDL-C and coronary artery disease (CAD); the association between TaqIB genotype and CAD risk was also largely mediated through HDL-C plasma levels [20]; this confirmed SNP was reported to be in strong LD with the rs1800775 promoter polymorphism [11, 21] and in moderate LD with rs3764261 (r2 = 0.44) [22]; however this variant is not itself functional and it may represent a marker due to its LD with a functional variant [21, 23].