Qi et al. found the discrepancy between the Phlegm_Dampness constitution and non-Phlegm_Dampness constitution of obesity in ATP binding gene including Janus kinase 2, nuclear receptor protein, and CDC1 [36], providing molecular biological evidence for the association between the Phlegm_Dampness constitution and overweight and obesity. Here, MPPE1 is linked to obesity due to melanocortin 4 receptor deficiency.