PXN and renal cell carcinoma: Based on our observation, we propose a potential mechanism in antcin-H-treated RCC cells, which shows that antcin-H suppressed FAK-related signaling pathway (Src, FAK, paxillin, and ERK1/2), which impaired focal adhesion turnover and lamellipodium formation, inactivated c-Fos and C/EBP-β, downregulated MMPs (especially MMP-7), and upregulated TIMPs (TIMP-3 and TIMP-4) expression (Figure 7).