On the basis of these results, we suggest that the anti-invasive activity of antcin-H is in part due to the inhibition of MMP-7 expression, which plays a critical role in cancer invasion and metastasis, through the suppression of ERK-mediated AP-1/c-Fos and C/EBP-β activities in RCC cells. The gene discussed is CEBPB; the disease is cancer.