Contrary to the destructive mechanism of IP10/CXCR3 axis, the MSP/RON signalling pathway plays a protective role in ulcerative colitis, so we continued to explore the possible protective mechanism of QCWZD in rats with DSS-induced UC from the opposite perspective, with the aim of providing a comprehensive experimental basis for the use of QCWZD. Here, CXCR3 is linked to ulcerative colitis.