MAPK8 and chronic obstructive pulmonary disease: This study was to evaluate the anti-inflammatory efficiency of Bufei Yishen granules, Shu-Fei Tie, and their combination in COPD rat model, and the results suggested that Bufei Yishen granules combined with Shu-Fei Tie therapy were beneficial for relieving lung and airway inflammation in COPD rats and that this effect was mediated via the downregulation of JNK and p38 MAPK signaling pathway.