TNFRSF1B and neoplasm: On the one hand, when mTNF-α acts as a ligand binding to TNFR2 on tumor cells, NF-κB activity is downregulated, which is followed by the subsequent inhibition of anti-apoptotic gene transcription, such as cIAP-1 and Fas-associated death domain-like IL-1β-converting enzyme-like inhibitory protein.