CMPK2 and viral infectious disease: In addition, the level of the lncRNA CMPK2 is dramatically higher in the liver of HCV-infected patients compared with healthy donors, indicating that the lncRNA CMPK2 also plays a regulatory role in viral infections in vivo (25), whereas overexpression of the lncRNA CMPK2 inhibits the transcription of ISGs, such as CMPK2 and viperin.