Formation of cyclic GMP-AMP (cGAMP) can trigger activation of the Stimulator of Interferon Genes (STING) protein which induces transcription of interferon β (IFNβ) as part of the innate immune response in antiviral, antibacterial, and anticancer activity and is suspected of involvement in autoinflammatory and autoimmune diseases (94). Here, STING1 is linked to autoimmune disease.