TOP2A and breast cancer: In conclusion, the identified 50 hub genes that were closely correlated with the TNM staging of BC patients, and 11 hub genes (MMP11, COL5A2, CDC25B, TOP2A, CENPF, CDCA3, TK1, TPX2, CDCA8, AEBP1, and FOXM1) of which were significantly correlated with the overall survival of BC, which could be candidate biomarkers for BC.