In the current study, we assessed the genetic alterations of HER-2/neu, c-myc and p53 genes using fluorescence in situ hybridization (FISH) in Egyptian benign prostatic hyperplasia patients and investigated the prognostic role of the three markers and their relation to each other and to demonstrate their relation to the classical clinicopathological factors. This evidence concerns the gene MYC and benign prostatic hyperplasia.