It was observed that the tumor volume and weight in the miR-155-5p mimic group were markedly increased in comparison with those in the CTHRC1 group, indicating that miR-155-5p functioned in a tumor-suppressive role in HCC by inhibiting CTHRC1 expression and that CTHRC1 functioned in a tumor-promoting role in HCC by miR-155-5p regulation. Here, CTHRC1 is linked to hepatocellular carcinoma.