IL36RN and psoriasis vulgaris: More recently, deficiency of IL-1 receptor antagonist (IL-1RN) was reported to cause an autoinflammatory disease with skin involvement12, mutations of the interleukin-36-receptor antagonist (IL-36RN) were shown to cause generalized pustular psoriasis13, and expression of IL36G was reported to distinguish lesions of psoriasis vulgaris from those of other erythemato-squamous skin diseases, such as atopic dermatitis and lichen planus14,15.