In addition, Junb deletion did not affect the induction of psoriasis-associated genes such as Defb4, Il17f, S100a9, and Il19 in imiquimod-treated skin lesions, although the mRNA level of the two other associated genes IIl23a and Il24 in Junb-deficient mice was slightly higher than that in control mice at day 5 after imiquimod treatment (Supplementary Figure 5B). The gene discussed is JUNB; the disease is psoriasis.