For instance, the correlation between CX3CL1 expression and the poor prognosis of cancer patients varies depending on the type of cancer: in colorectal cancer and gastric adenocarcinomas, high CX3CL1 expression is associated with better prognosis62,63; however, the opposite outcome is observed in breast cancer and hepatocellular carcinoma64,65. Here, CX3CL1 is linked to breast cancer.