TP53 and cancer: Alternatively or additionally, HSF1 can function as an oncoprotein,43 and HSF1‐mediated HSR contributes to stress resistance, which can be hijacked by malignant cells to promote oncogenesis.43,44 A large body of literature has provided evidence for constitutive HSF-1 activation in cancer cell growth, invasion, and metastasis.44,45 In the mouse, Hsf1 knockout reduces Trp53 deficiency-triggered tumorigenesis and chemically induced skin carcinogenesis.43,46 Thus, inactivating or dampening HSFR may minimize the oncogenic potential of normal cells.