NRIP1 and early-onset autosomal dominant Alzheimer disease: For instance, ER stress such as Aβ induces a fraction of RIP140 translocation to the cytosol to modulate IP3R activity and attenuate uncontrolled Ca2+ release in neuron.38 Further, sub-chronic psychological stress reduces RIP140 protein expression in astrocyte and disrupts brain cholesterol homeostasi.s39,40 Importantly, RIP140 expression is enriched in cortex and hippocampus, areas associated with Alzheimer’s disease (AD) pathology, and its expression is lower in AD postmortem brains.41 All these observations suggest that RIP140 can be a stress modulator in the brain.