HSF1 and Alzheimer disease: To this end, HSR plays an important role in modulating these stress responses.1,55,56 HSF1 and HSPs (molecular chaperones), especially HSP70, have been proposed as potential therapeutics for these diseases, and demonstrated in neurodegenerative disease models.57–59 Interestingly, RIP140 is enriched in cortex and hippocampus, areas associated with AD pathology.