KRAS and lung adenocarcinoma: KrasG12A, KrasG12C, and KrasG12V—the next most frequent KRAS variants in lung adenocarcinoma in never-smokers after KRASG12D—were identified as moderate drivers of lung tumorigenesis, but were present in fewer tumors than KrasG12D (Fig. 6b–e and Supplementary Fig. 11a–e).