TFEB and mucopolysaccharidosis type 3A: Overexpression of TFEB also causes reduction in substrate accumulation in various cell models of Pompe disease, MSD, MPS-II, MPS-IIIA and Batten disease [150,155,156], although it did not rescue the lysosomal depletion phenotype in neuronal cells differentiated from Gaucher disease patient-derived iPSCs [91].