Similarly, lysosomal exocytosis and reduction in cellular vacuolization occur after TFEB overexpression in various cell and mouse models of LSDs, including multiple sulfatase deficiency (MSD) and mucopolysaccharidosis type IIIA (MPS-IIIA) where a block in autophagy was previously reported [155,158]. The gene discussed is TFEB; the disease is mucopolysaccharidosis type 3A.