Mouse models of Gaucher disease have also revealed similar autophagy phenotypes: accumulation of various autophagic cargo such as dysfunctional mitochondria, ubiquitinated protein aggregates, insoluble α-synuclein and p62, together with autophagosomes and lysosomes were found in the brain or neurons and astrocytes cultured from mice deficient for Gba, Psap or glucosylceramidase [93–96]. Here, GBA1 is linked to Gaucher disease.