In addition to the relatively small patient population, other limitations of the current study can be considered to be that MDA, SOD and serum prolidase activities in the prostatic tissues were not studied, other markers such as total antioxidant status (TAS), total oxidant status (TOS), NO level, vitamins (C and E), glutathione peroxidase (GPx), glutathione-S-transferase (GST) were not examined and metastatic evaluation of PCa patients was not performed. Here, PEPD is linked to posterior cortical atrophy.