HER3 overexpression was associated with depth of invasion (OR = 2.39, 95%CI 1.62–3.54, P < 0.001) and lymph node metastasis (OR = 2.35, 95%CI 1.34–4.11, P = 0.003). The gene discussed is ERBB3; the disease is metastatic malignant neoplasm in the lymph nodes.