ERBB3 and metastatic malignant neoplasm in the lymph nodes: As shown in Table 6, positive HER3 expression was related to depth of invasion (OR = 2.39, 95%CI 1.62–3.54, P < 0.001, Fig. 5a) and lymph node metastasis (OR = 2.35, 95%CI 1.34–4.11, P = 0.003, Fig. 5b).