Meanwhile, p-mTOR was significantly associated with age (OR = 1.46, 95%CI 1.24–1.72, P < 0.001), tumor location (OR = 1.26, 95%CI 1.03–1.55, P = 0.03), depth of invasion (OR = 1.63, 95%CI 1.08–2.45, P = 0.02, Fig. 5c), and TNM stage (OR = 1.73, 95%CI 1.29–2.32, P < 0.001, Fig. 5d). Here, MTOR is linked to neoplasm.