After stratified according to ethnicity, CHI3L1 rs4950928 variant was associated with decreased asthma risk in Caucasians (GG + GC vs. CC: OR = 0.621, 95% CI = 0.484–0.797, P = 0.000; GC vs. CC: OR = 0.612, 95% CI = 0.470–0.796, P = 0.000; G vs. C: OR = 0.696, 95% CI = 0.567–0.856, P = 0.001). This evidence concerns the gene CHI3L1 and asthma.