Further study has shown that YKL-40 regulates TH2 immune response promoting airway inflammation in asthmatic mouse models as well as actives Akt, Erk, and p38 signaling pathway to promote human bronchial smooth muscle cell proliferation and migration, suggesting that YKL-40 is associated with the pathogenesis of asthma [27]. This evidence concerns the gene AKT1 and asthma.