Therefore, in the present study, we performed a quantitative trait interaction analysis testing modifiable effects of statins on the association between PON1 Q192R polymorphism and glycemia, such as fasting plasma glucose, HbA1c, insulin secretion measured by serum C-peptide and HOMA2-%β, and insulin resistance measured by HOMA2-IR, in Japanese patients with type 2 diabetes. Here, PON1 is linked to type 2 diabetes mellitus.