P2RY12 and pulmonary embolism: It is worth mentioning that the possible associations of P2RY12 genetic variants, in a “gain-of-function” haplotype H2 of P2Y12, with thromboembolic events (myocardial infarction (MI), IS, or deep venous thromboembolism/pulmonary embolism (DVT/PE)), were not confirmed in a prospective analysis of 14,916 initially healthy American men [17].