One out of four cases of adenosquamous carcinoma were positive for EGFR mutation (Table 1); this patient tested positive for exon 21 mutation (L858R) and was given 150 mg erlotinib for only 50 days, experienced initial symptomatic improvement but then rapidly deteriorated, and was enrolled into hospice care and expired shortly thereafter. The gene discussed is EGFR; the disease is adenosquamous carcinoma.