EGFR and non-small cell lung carcinoma: The Iressa Pan-Asia Study (IPASS) and the European erlotinib versus chemotherapy trial (EURTAC) showed improved progression-free survival (PFS) when gefitinib or erlotinib was given as first-line therapy for EGFR mutation-positive patients with metastatic NSCLC compared to first-line standard chemotherapy [9,17,18].