GNRH1 and rheumatoid arthritis: This has motivated for further clinical studies on GnRH antagonists: “A Study to Evaluate the Pharmacokinetics of ASP1707 and Methotrexate in Patients with Rheumatoid Arthritis” and “A Study to Evaluate the Efficacy and Safety of ASP1707 in Postmenopausal Female Patients with Rheumatoid Arthritis Taking Methotrexate”.