REC-8 localizes to the nucleus of germ cells in the mitotic cycle [30] and REC-8 was nuclear throughout the tumor (Figs 3E and 3G, S4I and S4J); PH3 marks M-phase [31] and was seen in dividing cells throughout the tumor (Fig 3F and 3H); and PGL-1 marks germ cells [32] and also was found throughout the tumor (S4C and S4D Fig). This evidence concerns the gene SDHD and neoplasm.