Next, to determine the effect of CXCR4 antagonism on the systemic cytokine environment during sepsis, we studied the levels of multiple circulating pro-inflammatory (Fig 8A) and anti-inflammatory cytokines (Fig 8B) known to be elevated in sepsis in sham controls, CLP animals, and CLP animals treated with plerixafor. This evidence concerns the gene CXCR4 and Sepsis.