To determine the effect of CXCR4 blockade on the number of peripheral T cells during sepsis, spleens were harvested at 24h from sham, septic control mice (CLP), and septic mice treated with plerixafor (CLP+Plerixafor), and absolute counts of CD4+ T cells and CD8+ T cells were analyzed. The gene discussed is CXCR4; the disease is Sepsis.